Ultima Short Read Sequencing

Platform

CPM has developed a new collaboration with UMN Genomics Center to provide streamlined access to Ultima Genomics short read sequencing. The UG100 uses an approach that’s quite different from traditional flow cell–based sequencing, and while it won’t be the perfect fit for every project, it brings some great advantages. It’s more cost effective, delivers a median read length of ≥300 bases (typically around 250 bases after filtering), and produces 10–12 billion reads per wafer—which means 2.5–3.0 terabytes of high quality data in a single run.

Potential Applications

• Whole genome sequencing for any organism
• Paired plus-minus sequencing (ppmSeq) for rare event detection
• Minimal residual disease detection
• Analysis of cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA)
• Ultra-deep metagenomic sequencing
• Model organism and cell line sequencing for quality control
• DNA methylation sequencing via WGBS or RRBS
• Ultra high-depth single-cell sequencing (10X Genomics, Parse, Scale)